Charles F. Reynolds III MD’s academic affiliation is as Distinguished Professor of Psychiatry and UPMC Endowed Professor in Geriatric Psychiatry (emeritus) at the University of Pittsburgh School of Medicine. Before becoming emeritus on July 1, 2017, I also served as Professor of Behavioral and Community Health Science at the Graduate School of Public Health, in addition to serving as  Director of the Aging Institute of UPMC Senior Services and the University of Pittsburgh Schools of Health Sciences ( I directed the NIMH-sponsored Advanced Center for Interventions and Services Research in the Prevention and Treatment of Late-Life Mood Disorders (1995-2017) and the John A. Hartford Center of Excellence in Geriatric Psychiatry (2005-2017). The themes of my research program encompass 1) prevention of depression and its complications in older adults in both high-income, and in low- and middle-income countries; 2) understanding treatment response variability from biological and psychosocial perspectives and applying that understanding to the development and testing of new ways to prevent and to manage difficult-to-treat depression in later life; and 3) devising and testing models of improved mental health services delivery for older disadvantaged (often minority) adults living with mood disorders. In addition, I have  collaborated in research on the diagnosis and treatment of Prolonged Grief Disorder (complicated grief). My CV includes over 830 peer-reviewed publications, with over 65,000 citations, with an H-Index of 109 as of May 2023, as calculated using Clarivate/Web of Science.

  Selected Publications Relevant to Social Determinants  of Health

  1. Reynolds CF, Jeste DV, Sachdev PS, Blazer DG. Mental health care for older adults: recent advances and new directions in clinical practice and research. World Psychiatry 2022;21:336–363. doi:10.1002/wps.20996.
  2. Schuster J, Nikolajski C, Kogan J, Kang C, Schake P, Carney T, Morton SC, Reynolds III CF. A Payer-Guided Approach to Widespread Diffusion of Behavioral Health Homes in Real-World Settings. Health Affairs. 2018 Feb 1;37(2):248-56.
  3. Dias A, Azariah F, Anderson SJ, Sequeira M, Cohen A, Morse JQ, Cuijpers P, Patel V, Reynolds CF 3rd. Effect of a Lay Counselor Intervention on Prevention of Major Depression in Older Adults Living in Low- and Middle-Income Countries: A Randomized Clinical Trial.  JAMA Psychiatry. 2019 Jan 1;76(1):13-20. doi: 10.1001/jamapsychiatry.2018.3048 PMID: 30422259; PMCID: PMC6583466.
  4. Cuijpers P, Beekman AT, Reynolds CF 3rd. Preventing depression: a global priority. Journal of the American Medical Association. 2012 Mar 14;307(10):1033-4. PubMed PMID: 22416097; PMCID: PMC3397158.
  5. Reynolds CF 3rd, Thomas SB, Morse JQ, Anderson SJ, Albert S, et al. Early intervention to preempt major depression among older black and white adults. Psychiatric Services 2014 Jun 1;65(6):765-73. PubMed PMID: 24632760; PMCID: PMC4050338.
  6. Shear MK, Reynolds CF, Simon NM, Zisook S, et al. Optimizing treatment of complicated grief: a randomized clinical trial. JAMA Psychiatry 2016; July 1 73(7): 685-94.
  7. Eric J. Lenze, M.D.1, Benoit H. Mulsant, M.D.2,3, Steven P. Roose, M.D.4, Helen Lavretsky, M.D.5, Charles F. Reynolds III, M.D.6, Daniel M. Blumberger, M.D.2,3, Patrick J. Brown, Ph.D.4,  Pilar Cristancho, M.D.1, Alastair J. Flint, M.B.2,7, Marie Anne Gebara, M.D.6, Torie R. Gettinger, Ph.D.1, Emily Lenard, M.S.W.1, J. Philip Miller, A.B.8, Ginger E. Nicol, M.D.1, Hanadi Ajam Oughli, M.D.5, Vy T. Pham, M.D., M.P.H.1, Bruce L. Rollman, M.D., M.P.H.6, Lei Yang, M.P.H., M.S.I.S.1, and Jordan F. Karp, M.D.9   Trial of antidepressant augmentation vs. switching in treatment-resistant geriatric depression.  New England Journal of Medicine, published March 3, 2023.  DOI: 10.1056/NEJMoa2204462
  8. Prigerson HG, Shear MK, Reynolds CF. Prolonged grief disorder diagnostic criteria: helping those with maladaptive responses to grief. JAMA Psychiatry 2022;79:277. doi:10.1001/ jamapsychiatry.2021.4201.
  9.   Reynolds CF, Weissman MM. Transdisciplinary science and research training in psychiatry: a robust approach to innovation. JAMA Psychiatry 2022;79(9):839–840. doi:10.1001/ jamapsychiatry.2022.1788.
  10.  Herrman H, Patel V, Kieling C, …Reynolds C et al. Time for united action on depression: a Lancet-World Psychiatric Association Commission. Lancet. 2022 Mar;399(10328):957–1022. doi:10.1016/ S0140-6736(21)02141-3.
  11. National Academies of Sciences, Engineering, and Medicine. 2023. Addressing the Rising Mental Health Needs of an Aging Population: Proceedings of a Workshop. Washington, DC: The National Academies Press.
  12. Reynolds CF.  Reflections on a journey as sleep researcher and geriatric psychiatrist.  Living Legends in Sleep Research.  Sleep Advances  2023, 4, 1-5.