Deanna M. Barch, PhD
Deanna Barch is a clinical scientist whose research focuses on understanding normative patterns cognitive function and brain connectivity and the mechanisms that give rise to the challenges in behavior and cognition found in illnesses such as schizophrenia and depression, utilizing psychological, neuroimaging and computational approaches. She is the Vice Dean of Research in Arts & Sciences at Washington University. She is also the Couch Professor of Psychiatry and a Professor of Radiology. She is Deputy Editor at Biological Psychiatry and Editor-in-Chief of Biological Psychiatry: Global Open Science. She is also the President of the Psychology Section of the American Association for the Advancement of Science. Dr. Barch is on the scientific boards of the Brain and Behavior Research Foundation, the One Mind Foundation, and the Stanley Foundation. Dr. Barch was on the Executive Committee of the Association for Psychological Science and the Scientific Council of the National Institute of Mental Health. She is a Fellow of both the Association for Psychological Science and the American College of Neuropsychopharmacology, a member of the Society for Experimental Psychology, and a member of the National Academy of Medicine and the American Academy of Arts & Sciences.
Papers relevant to SDoH:
Luby, J. L., Barch, D. M., Belden, A., Gaffrey, M., Tillman, R., Babb, C., Nishino, T., Suzuki, H., and Botteron, K. (2012). Maternal support in early childhood predicts larger hippocampal volumes at school age. Proceedings of the National Academy of Sciences, 109, 2854-2859. PMCID: PMC3286943
Luby, J. L., Belden, A., Botteron, K., Marrus, N., Harms, M. P., Babb, C., Nishino, T., & Barch, D. M. (2013). The effects of poverty on childhood brain development: The mediating effect of caregiving and stressful life events. JAMA: Pediatrics, 167, 1135-1142. PMCID: PMC4001721
Pagliaccio, D., Luby, J. L., Bogdan, R., Agarwal, A., Gaffrey, M. S., Belden, A. C., Botteron, K. N., Harms, M. P., & Barch, D. M. (2104). Stress system genetic variation and early life stress predict cortisol levels in preschool age children and left amygdala and hippocampal volume at school age. Neuropsychopharmacology, 39, 1245-1253. PMCID: PMC3957120
Sukuki, H, Luby, J. L., Botteron, K. N., Dietrich, R., Barch, D. M. (2014). Early life stress and trauma and enhanced limbic activation to negative emotion faces in children. Journal of the American Academy of Child and Adolescent Psychiatry, 53, 800-813. PMCID: PMC4086855
Barch, D. M., *Pagliaccio, D., Belden, A., Harms, M. P., Gaffrey, M. S., Sylvester, C., Tilman, R., & Luby, J. L. (2016). Effect of hippocampal and amygdala connectivity on the relationship between preschool poverty and school-age depression. American Journal of Psychiatry, 173, 625-634. PMCID: PMC4932860
Luby, J. L., Belden, A. C., Whalen, D., Harms, M. P., Barch, D. M. (2016). Preschool is a sensitive period for the influence of maternal support on the trajectory of hippocampal development. Proceedings of the National Academy of Sciences, 113, 5742-5747. PMCID: PMC4878487
Whalen, D. J., Belden, A. C., Tilman, B., Barch, D. M., & Luby, J. L. (2016). Early adversity, psychopathology and latent class profiles of global physical health from preschool through early adolescence. Psychosomatic Medicine, 78, 1008-1018. PMCID: PMC5108573
Luby, J. L., Barch, D. M., Whalen, D., Tillman, R., & Belden, A. (2017). Association between early life adversity and risk for poor emotional and physical health in adolescence: A putative mechanistic neurodevelopmental pathway. JAMA Pediatrics, 171, 1168-1175
Barch, D. M., Belden, A. C., Tillman, R., Whalen, D. & Luby, J. L. (2018). Early adverse childhood experiences, inferior frontal gyrus connectivity and the trajectory of externalizing psychopathology. Journal of the American Academy of Child Psychiatry, 57, 183-190. PMCID: PMC5836492
Fine, J. D., Moreau, Al., Karcher, N., R., Agarwal, A., Rogers, C.E., Barch, D. M., and Bogdan, R. (2019). Prenatal cannabis exposure is predictive of increased psychosis proneness among children: Results from the Adolescent Brain Cognitive Development (ABCD) study. JAMA Psychiatry, 76, 762-764. PMCID: PMC6583849
Luby, J. L., Tillman, R., Gilbert, K., & Barch, D. M. (2019). Association of timing of adverse life experiences and caregiver support in childhood: Regionally specific effects on brain development. JAMA Open Network, 2, e1911426. PMCID: PMC6751767
Barch, D. M., Shirtcliff, E. A., *Elsayed, N. M., Whalen, D., Gilbert, K., Vogel., A. C., Tillman, R., & Luby, J. L. (2020). Testosterone and hippocampal trajectories mediate relationship of poverty to emotion dysregulation and depression: A longitudinal study. Proceedings of the National Academy of Sciences, 117, 22015-22023. PMCID: PMC7486761
Karcher, N. R. Niendam, T. A., & Barch, D. M. (2020). Adverse childhood experiences and psychotic-like experiences are associated above and beyond shared correlates: Findings from the Adolescent Brain and Cognitive Development Study. Schizophrenia Research, 222, 235-242. PMCID: PMC7572890
Luby, J., Tallie, B. Z., Rogers, C., & Barch, D. M. (2020). Early experience and brain development: Informing a new science of neurodevelopmental optimization during early childhood. Trends in Neurosciences, 43, 744-751. PMCID: PMC7530018
Taylor, R. L., Cooper, S. R., Jackson, J. J., & Barch, D. M. (2020). Neighborhood poverty as an independent predictor of brain volume and cognitive performance in children. JAMA Network Open, 3(11): e2023774
Elsayed, N. M., *Rappaport, B. I., Luby, J. L., & Barch, D. M. (2021). Evidence for dissociable cognitive and neural pathways from poverty versus maltreatment to deficits in emotion regulation. Developmental Cognitive Neuroscience, 49, 100952. PMCID: PMC8050852
Karcher, N. R. Shiffman, J. E., & Barch, D. M. (2021). Environmental risk factors and psychotic-like experiences in children aged 9-11. Journal of the American Academy of Child and Adolescent Psychiatry, 60, 490-500. PMCID: PMC7895444
Paul, S. E., Hatoum, A., Hansen, I., #Fine, J. D., Johnson, E., Moreau, A. L., *Bondy, E., #Qu, Yueyue, Karcher, N. R., Carter, E., B, Rogers, C. E., Agrawal, A., Barch, D. M., Bogdan, R. (2021). Prenatal cannabis exposure and childhood outcomes: Results from the ABCD Study. JAMA Psychiatry, 78, 64-76. PMCID: PMC7512132
Silver, J., Barch, D. M., Klein, D., Whale, D. J., Hennefield, L., Tilman, R., & Luby., J. L. (2021). A brief early childhood screening tool for psychopathology risk in primary care: The moderating role of poverty. The Journal of Pediatrics, 236, 164-171: PMCID: PMC8403161
Barch, D. M., Donohue, M. R., *Elsayed, N. M., Gilbert, K., Harms, M. P., Hennefield, L., Herzberg, M., Kandala, S., Karcher, N. R., Jackson, J. L., Luking, K. R., Rappaport, B. I., Sanders, A., *Taylor, R., Tillman, R., Vogel, A. C., Whalen, D., & Luby, J. L. (2022). Early childhood poverty and cognitive and adaptive outcomes at the transition to adulthood: The mediating role of gray matter development across 5 scan waves. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 7, 34-44. PMCID: PMC8917509
Brady, R. G., Rogers, C. E., Prochaska, T., Kaplan, S., Lean, R. E., Smyser, T. A., Warner, B. B., Barch, D. M., Luby, J. L., & Smyser, C. D. (2022). The effects of exposure to neighborhood crime during pregnancy on neonatal functional connectivity. Biological Psychiatry, 92, 139-148. PMCID: PMC9257309
Hatzenbuehler, M. L., Weissman, D. G., Lattanner, M. R., Ford, J. V., Barch, D. M., & McLaughlin, K. A. (2022). Smaller hippocampal volume among black and Latinx youth living in high-stigma contexts. Journal of the American Academy of Child and Adolescent Psychiatry, 61, 809-819. PMCID: PMC8888779
Herzberg, M. P., Tillman, R., Kandala, S., Barch, D. M., & Luby, J. L. (2022). Preschool depression and hippocampal volume: The moderating role of family income. Journal of the American Academy of Child and Adolescent Psychiatry, 61, 1362-1371. PMCID
Lean, R. E., Smyser, C. D., Brenner, R. G., Riplett, R., Kaplan, S., Kenley, J., Luby, J. L., Barch, D. M., Warner, B. B., Miller, J. P., & Rogers, C.E. (2022). Exposure to prenatal social disadvantage and maternal psychosocial stress: Relationships to neonatal structural connectivity. Proceedings of the National Academy of Sciences, 119, e2204135119. PMCID: PMC9586270
Luby, J. L., Constantino, J. N., & Barch, D. M. (2022). Poverty and the developing brain. Cerebrum, Mar 1, cer-04-33. PMCID: PMC9224364
Taylor, R., & Barch, D. M. (2022). The development of inhibitory control within the context of early life poverty and implications for outcome. Neuroscience and Biobehavioral Reviews, 140: 104778
Triplett, R. L., Lean, R. E. Parikh, A., Miller, P. J., Alexopoulos, D., Kaplan, S., Meyer, D., Adamson, C., Smyser, T. A., Rogers, C. E., Barch, D. M., Warner, B., Luby., J. L. & Smyser, C. D. (2022). Association of prenatal exposure to early life adversity and neonatal brain volumes at birth. JAMA Network Open, 5: e227045. PMCID: PMC9006107
Harnett N. G., Fani N., Carter S., Sanchez L. D., Rowland G. E. , Davie W. M. , Guzman C., Lebois LAM, Ely TD, van Rooij SJH, Seligowski AV, Winters S, Grasser LR, Musey PI, Seamon MJ, House SL, Beaudoin FL, An X, Zeng D, Neylan TC, Clifford GD, Linnstaedt SD, Germine LT, Bollen KA, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Hendry PL, Sheikh S, Jones CW, Punches BE, Swor RA, Hudak LA, Pascual JL, Harris E, Chang AM, Pearson C, Peak DA, Merchant RC, Domeier RM, Rathlev NK, Bruce SE, Miller MW, Pietzrak RH, Joorman J, Barch D. M., Pizzagalli DA, Harte SE, Elliott JM, Kessler RC, Koenen KC, McLean SA, Jovanovic T, Stevens JS, Ressler KJ. (in press). Structural inequities contribute to racial/ethnic differences in neurophysiological tone, but not threat reactivity, after trauma exposure. Molecular Psychiatry.
Herzberg, M. P., Hennefield, L., Luking, K. R., Sanders, A. F. P., Vogel, A. C., Kandala, S., Tillman, R., Luby, J. L., & Barch, D. M. (in press). Family income moderates the relationship between adverse experiences in childhood and putamen volume. Developmental Neurobiology
Herzberg, M. P., Triplett, R., McCarthy, R., Kaplan, S., Alexopoulos, D., Meyer, D., Arora, J., Miller, J. P., Smyser, T. A., Herzog, E., England, S. K., Zhoa, P., Barch, D. M., Rogers, C. E., Warner, B., Smyser, C. D., & Luby, J. (in press). The association between maternal cortisol and infant amygdala volume is moderated by socioeconomic status. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Luby, J. L., Barch, D. M., Warner, B., Rogers, C.E., Smyser, C.D., Arora, J., Smyser, T.A., Engand, S., Stout, M., & Miller, P. (in press). Modeling prenatal adversity/advantage: Effects on gestational age and birthweight. Journal of Perinatology
Maxwell, M. Y., Taylor, R. L., & Barch, D. M. (in press). Relationship between neighborhood poverty and externalizing symptoms in children: Mediation and moderation by environmental factors and brain structure. Child Psychiatry and Human Development.
Barch, D. M. & Luby, J. L. (2023). Understanding social determinants of brain health during development: A commentary on Dumornay et al. (in press). American Journal of Psychiatry, 180, 108-110