Deanna M. Barch, PhD

Deanna Barch is a clinical scientist whose research focuses on understanding normative patterns cognitive function and brain connectivity and the mechanisms that give rise to the challenges in behavior and cognition found in illnesses such as schizophrenia and depression, utilizing psychological, neuroimaging and computational approaches. She is the Vice Dean of Research in Arts & Sciences at Washington University.  She is also the Couch Professor of Psychiatry and a Professor of Radiology. She is Deputy Editor at Biological Psychiatry and Editor-in-Chief of Biological Psychiatry: Global Open Science. She is also the President of the Psychology Section of the American Association for the Advancement of Science. Dr. Barch is on the scientific boards of the Brain and Behavior Research Foundation, the One Mind Foundation, and the Stanley Foundation. Dr. Barch was on the Executive Committee of  the Association for Psychological Science and the Scientific Council of the National Institute of Mental Health. She is a Fellow of both the Association for Psychological Science and the American College of Neuropsychopharmacology, a member of the Society for Experimental Psychology, and a member of the National Academy of Medicine and the American Academy of Arts & Sciences.   

Papers relevant to SDoH:

Luby, J. L., Barch, D. M., Belden, A., Gaffrey, M., Tillman, R., Babb, C., Nishino, T., Suzuki, H., and Botteron, K. (2012). Maternal support in early childhood predicts larger hippocampal volumes at school age. Proceedings of the National Academy of Sciences, 109, 2854-2859. PMCID: PMC3286943

Luby, J. L., Belden, A., Botteron, K., Marrus, N., Harms, M. P., Babb, C., Nishino, T., & Barch, D. M. (2013). The effects of poverty on childhood brain development: The mediating effect of caregiving and stressful life events. JAMA: Pediatrics, 167, 1135-1142. PMCID: PMC4001721

Pagliaccio, D., Luby, J. L., Bogdan, R., Agarwal, A., Gaffrey, M. S., Belden, A. C., Botteron, K. N., Harms, M. P., & Barch, D. M. (2104). Stress system genetic variation and early life stress predict cortisol levels in preschool age children and left amygdala and hippocampal volume at school age. Neuropsychopharmacology, 39, 1245-1253. PMCID: PMC3957120

Sukuki, H, Luby, J. L., Botteron, K. N., Dietrich, R., Barch, D. M. (2014). Early life stress and trauma and enhanced limbic activation to negative emotion faces in children. Journal of the American Academy of Child and Adolescent Psychiatry, 53, 800-813. PMCID: PMC4086855

Barch, D. M., *Pagliaccio, D., Belden, A., Harms, M. P., Gaffrey, M. S., Sylvester, C., Tilman, R., & Luby, J. L. (2016). Effect of hippocampal and amygdala connectivity on the relationship between preschool poverty and school-age depression. American Journal of Psychiatry, 173, 625-634. PMCID: PMC4932860

Luby, J. L., Belden, A. C., Whalen, D., Harms, M. P., Barch, D. M. (2016). Preschool is a sensitive period for the influence of maternal support on the trajectory of hippocampal development. Proceedings of the National Academy of Sciences, 113, 5742-5747. PMCID: PMC4878487

Whalen, D. J., Belden, A. C., Tilman, B., Barch, D. M., & Luby, J. L. (2016). Early adversity, psychopathology and latent class profiles of global physical health from preschool through early adolescence. Psychosomatic Medicine, 78, 1008-1018. PMCID: PMC5108573

Luby, J. L., Barch, D. M., Whalen, D., Tillman, R., & Belden, A. (2017). Association between early life adversity and risk for poor emotional and physical health in adolescence: A putative mechanistic neurodevelopmental pathway. JAMA Pediatrics, 171, 1168-1175

Barch, D. M., Belden, A. C., Tillman, R., Whalen, D. & Luby, J. L. (2018). Early adverse childhood experiences, inferior frontal gyrus connectivity and the trajectory of externalizing psychopathology. Journal of the American Academy of Child Psychiatry, 57, 183-190. PMCID: PMC5836492

Fine, J. D., Moreau, Al., Karcher, N., R., Agarwal, A., Rogers, C.E., Barch, D. M., and Bogdan, R. (2019). Prenatal cannabis exposure is predictive of increased psychosis proneness among children: Results from the Adolescent Brain Cognitive Development (ABCD) study. JAMA Psychiatry, 76, 762-764. PMCID: PMC6583849

Luby, J. L., Tillman, R., Gilbert, K., & Barch, D. M. (2019). Association of timing of adverse life experiences and caregiver support in childhood: Regionally specific effects on brain development. JAMA Open Network, 2, e1911426. PMCID: PMC6751767

Barch, D. M., Shirtcliff, E. A., *Elsayed, N. M., Whalen, D., Gilbert, K., Vogel., A. C., Tillman, R., & Luby, J. L. (2020). Testosterone and hippocampal trajectories mediate relationship of poverty to emotion dysregulation and depression: A longitudinal study. Proceedings of the National Academy of Sciences, 117, 22015-22023. PMCID: PMC7486761

Karcher, N. R. Niendam, T. A., & Barch, D. M. (2020). Adverse childhood experiences and psychotic-like experiences are associated above and beyond shared correlates: Findings from the Adolescent Brain and Cognitive Development Study. Schizophrenia Research, 222, 235-242. PMCID: PMC7572890

Luby, J., Tallie, B. Z., Rogers, C., & Barch, D. M. (2020). Early experience and brain development: Informing a new science of neurodevelopmental optimization during early childhood. Trends in Neurosciences, 43, 744-751. PMCID: PMC7530018

Taylor, R. L., Cooper, S. R., Jackson, J. J., & Barch, D. M. (2020). Neighborhood poverty as an independent predictor of brain volume and cognitive performance in children. JAMA Network Open, 3(11): e2023774

Elsayed, N. M., *Rappaport, B. I., Luby, J. L., & Barch, D. M. (2021). Evidence for dissociable cognitive and neural pathways from poverty versus maltreatment to deficits in emotion regulation. Developmental Cognitive Neuroscience, 49, 100952. PMCID: PMC8050852

Karcher, N. R. Shiffman, J. E., & Barch, D. M. (2021). Environmental risk factors and psychotic-like experiences in children aged 9-11. Journal of the American Academy of Child and Adolescent Psychiatry, 60, 490-500. PMCID: PMC7895444

Paul, S. E., Hatoum, A., Hansen, I., #Fine, J. D., Johnson, E., Moreau, A. L., *Bondy, E., #Qu, Yueyue, Karcher, N. R., Carter, E., B, Rogers, C. E., Agrawal, A., Barch, D. M., Bogdan, R. (2021). Prenatal cannabis exposure and childhood outcomes: Results from the ABCD Study. JAMA Psychiatry, 78, 64-76. PMCID: PMC7512132

Silver, J., Barch, D. M., Klein, D., Whale, D. J., Hennefield, L., Tilman, R., & Luby., J. L. (2021). A brief early childhood screening tool for psychopathology risk in primary care: The moderating role of poverty. The Journal of Pediatrics, 236,  164-171: PMCID: PMC8403161

Barch, D. M., Donohue, M. R., *Elsayed, N. M., Gilbert, K., Harms, M. P., Hennefield, L., Herzberg, M., Kandala, S., Karcher, N. R., Jackson, J. L., Luking, K. R., Rappaport, B. I., Sanders, A., *Taylor, R., Tillman, R., Vogel, A. C., Whalen, D., & Luby, J. L. (2022). Early childhood poverty and cognitive and adaptive outcomes at the transition to adulthood: The mediating role of gray matter development across 5 scan waves. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 7, 34-44. PMCID: PMC8917509

Brady, R. G., Rogers, C. E., Prochaska, T., Kaplan, S., Lean, R. E., Smyser, T. A., Warner, B. B., Barch, D. M., Luby, J. L., & Smyser, C. D. (2022). The effects of exposure to neighborhood crime during pregnancy on neonatal functional connectivity. Biological Psychiatry, 92, 139-148. PMCID: PMC9257309

Hatzenbuehler, M. L., Weissman, D. G., Lattanner, M. R., Ford, J. V., Barch, D. M., & McLaughlin, K. A. (2022). Smaller hippocampal volume among black and Latinx youth living in high-stigma contexts. Journal of the American Academy of Child and Adolescent Psychiatry, 61, 809-819. PMCID: PMC8888779

Herzberg, M. P., Tillman, R., Kandala, S., Barch, D. M., & Luby, J. L. (2022). Preschool depression and hippocampal volume:  The moderating role of family income. Journal of the American Academy of Child and Adolescent Psychiatry, 61, 1362-1371. PMCID

Lean, R. E., Smyser, C. D., Brenner, R. G., Riplett, R., Kaplan, S., Kenley, J., Luby, J. L., Barch, D. M., Warner, B. B., Miller, J. P., & Rogers, C.E. (2022). Exposure to prenatal social disadvantage and maternal psychosocial stress: Relationships to neonatal structural connectivity. Proceedings of the National Academy of Sciences, 119, e2204135119. PMCID: PMC9586270

Luby, J. L., Constantino, J. N., & Barch, D. M. (2022). Poverty and the developing brain. Cerebrum, Mar 1, cer-04-33. PMCID: PMC9224364

Taylor, R., & Barch, D. M. (2022). The development of inhibitory control within the context of early life poverty and implications for outcome. Neuroscience and Biobehavioral Reviews, 140: 104778

Triplett, R. L., Lean, R. E. Parikh, A., Miller, P. J., Alexopoulos, D., Kaplan, S., Meyer, D., Adamson, C., Smyser, T. A., Rogers, C. E., Barch, D. M., Warner, B., Luby., J. L. & Smyser, C. D. (2022). Association of prenatal exposure to early life adversity and neonatal brain volumes at birth. JAMA Network Open, 5: e227045. PMCID: PMC9006107

Harnett N. G., Fani N., Carter S., Sanchez L. D., Rowland G. E. , Davie W. M. , Guzman C., Lebois LAM, Ely TD, van Rooij SJH, Seligowski AV, Winters S, Grasser LR, Musey PI, Seamon MJ, House SL, Beaudoin FL, An X, Zeng D, Neylan TC, Clifford GD, Linnstaedt SD, Germine LT, Bollen KA, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Hendry PL, Sheikh S, Jones CW, Punches BE, Swor RA, Hudak LA, Pascual JL, Harris E, Chang AM, Pearson C, Peak DA, Merchant RC, Domeier RM, Rathlev NK, Bruce SE, Miller MW, Pietzrak RH, Joorman J, Barch D. M., Pizzagalli DA, Harte SE, Elliott JM, Kessler RC, Koenen KC, McLean SA, Jovanovic T, Stevens JS, Ressler KJ. (in press). Structural inequities contribute to racial/ethnic differences in neurophysiological tone, but not threat reactivity, after trauma exposure. Molecular Psychiatry.

Herzberg, M. P., Hennefield, L., Luking, K. R., Sanders, A. F. P., Vogel, A. C., Kandala, S., Tillman, R., Luby, J. L., & Barch, D. M. (in press). Family income moderates the relationship between adverse experiences in childhood and putamen volume. Developmental Neurobiology

Herzberg, M. P., Triplett, R., McCarthy, R., Kaplan, S., Alexopoulos, D., Meyer, D., Arora, J., Miller, J. P., Smyser, T. A., Herzog, E., England, S. K., Zhoa, P., Barch, D. M., Rogers, C. E., Warner, B., Smyser, C. D., & Luby, J. (in press). The association between maternal cortisol and infant amygdala volume is moderated by socioeconomic status. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

Luby, J. L., Barch, D. M., Warner, B., Rogers, C.E., Smyser, C.D., Arora, J., Smyser, T.A., Engand, S., Stout, M., & Miller, P. (in press). Modeling prenatal adversity/advantage:  Effects on gestational age and birthweight. Journal of Perinatology

Maxwell, M. Y., Taylor, R. L., & Barch, D. M. (in press). Relationship between neighborhood poverty and externalizing symptoms in children: Mediation and moderation by environmental factors and brain structure. Child Psychiatry and Human Development.

Barch, D. M. & Luby, J. L. (2023). Understanding social determinants of brain health during development: A commentary on Dumornay et al. (in press). American Journal of Psychiatry, 180, 108-110